Giant gastric lipoma mimicking well-differentiated liposarcoma

Giant gastric lipoma mimicking well-differentiated liposarcoma

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Authors report Pot Holders the case of a 51-year-old man, presenting with epigastralgia of recent onset.Physical exam was unremarkable.Endoscopy revealed a large, ulcerated, submucosal, antral tumor.CT scan reveals an antral mass with fat attenuation.

The patient underwent a total gastrectomy.Macroscopic examination identified in the antral wall a 9-cm, well-circumscribed, nodular lesion, with a yellow, greasy cut surface.On histological examination, the tumor was composed of a mature adipocytes proliferation, showing significant variation in cell size, associated to some lipoblasts.Nuclei were sometimes large, slightly irregular, but without hyperchromasia nor mitosis.

Diagnosis of a well-differentiated liposarcoma was suspected and One-of-a-kind Hair-On Hides molecular cytogenetic analyses showed no MDM2 nor CDK4 gene amplification on fluorescent in situ hybridization.The diagnosis of lipoma was made.Twelve months following surgery, the patient is doing well.